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Population genomics reveals multi-scale mechanisms sustaining schistosomiasis re-emergence in a near-elimination setting
In China, sustained snail control, environmental management, and mass drug administration with praziquantel reduced schistosomiasis to near-elimination levels, yet re-emergence in Sichuan Province during the early 2000s exposed vulnerabilities in elimination efforts. We used population genomics to investigate the multi-scale…
Identification of Promising Candidate Genes and Immune Infiltration Patterns in Chronic Schistosomiasis-Associated Liver Injury by WGCNA and Machine Learning
Background: Dysregulated immune cells contribute to Schistosoma japonicum-induced liver injury. However, the underlying mechanisms remain poorly understood. This study aimed to identify feature genes and immune infiltration patterns linked to chronic schistosomiasis-associated liver injury. Methods: Differential gene expression analysis was…
Preparation of monoclonal antibodies against Echinococcus multilocularis CIP2A and development of blocking and sandwich ELISAs
Alveolar echinococcosis (AE), caused by the metacestode stage of Echinococcus multilocularis, is a highly lethal zoonosis. Its insidious progression frequently precludes diagnosis until advanced stages, and the paucity of effective early detection tools remains a critical impediment to disease control.…
A nationwide epidemiological update on respiratory and intestinal nematodes in at-risk dogs in Italy
This study updates current information on the occurrence of Capillaria aerophila, Capillaria boehmi and Angiostrongylus vasorum infections in dogs from Italy, along with the evaluation of the occurrence of intestinal parasites. Fecal samples collected from a total of 2000 dogs…
Spatial and seasonal dynamics of Simulium damnosum s.l. and entomological indicators of onchocercosis in the provinces of Huambo and Cuanza-Sul in Angola
CONCLUSION: Despite high vector density and relatively old black fly populations, the absence of transmission suggests a reduction in onchocerciasis transmission in the studied regions. These results demonstrate the importance of maintaining regular entomological surveillance to prevent potential transmission in…
In vitro sexual dimorphism establishment in schistosomes
Schistosomes are parasitic flatworms that cause Schistosomiasis, a major neglected tropical disease that affects more than 250 million people worldwide. With two distinct sexes, a heterogametic female (ZW) and a homogametic male (ZZ), schistosomes are an exception among flatworms, which…
Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics
Parasites and allergic diseases are linked by a complex, bidirectional relationship shaped by long-term host-parasite coevolution. This review discusses how different parasites may either promote or attenuate allergic responses through immunological, epithelial, and microbiome-mediated mechanisms. IgE-mediated immunity, mast cell activation,…
Interpretable machine learning and signal processing for automated reading and quality control of lateral flow tests for schistosomiasis – Nature
Interpretable machine learning and signal processing for automated reading and quality control of lateral flow tests for schistosomiasis Nature
Albendazole–ivermectin co-formulation for the treatment of Trichuris trichiura and other soil-transmitted helminths: a randomised phase 2/3 trial – The Lancet
Albendazole–ivermectin co-formulation for the treatment of Trichuris trichiura and other soil-transmitted helminths: a randomised phase 2/3 trial The Lancet
TWiP 287: A Vaccine Against Schistosomiasis? SchistoShield Heads to Phase 2 – YouTube
TWiP 287: A Vaccine Against Schistosomiasis? SchistoShield Heads to Phase 2 YouTube